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Search Results for " mitochondrial metabolism "

59

抑制剂 & 化合物

21

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9372	D-Histidine	Mitochondrial Metabolism	Metabolism
	D-Histidine 是一种 L-histidine 的对映体。其中 L-histidine 是婴儿必需的氨基酸，是一种线粒体谷氨酰胺转运的抑制剂。
T9777	THP104c	Mitochondrial Metabolism	Metabolism
	THP104c 是有效的线粒体分裂抑制剂。
T15373	Gboxin	ATPase; Mitochondrial Metabolism	Membrane transporter/Ion channel; Metabolism
	Gboxin 是一种氧化磷酸化抑制剂，可靶向抑制胶质母细胞瘤生长，还抑制 F0F1 ATP 合成，具有抗肿瘤活性。
T12408	Perhexiline maleate	Others; Mitochondrial Metabolism	Metabolism; Others
	Perhexiline maleate 是一种口服活性的 CPT1和 CPT2抑制剂，可降低脂肪酸的代谢。Perhexiline maleate 对大鼠心脏和肝脏CPT 1的IC50值分别为77 和 148 μM。
T9232	Mitochondrial fusion promoter M1	Mitochondrial Metabolism	Metabolism
	Mitochondrial fusion promoter M1 是一种线粒体动态调节剂，能够保持线粒体功能并促进细胞呼吸，减轻心肌缺血/再灌注大鼠的心脏损伤和大脑损伤。
T1768	7ACC2	Mitochondrial Metabolism; Monocarboxylate transporter	Membrane transporter/Ion channel; Metabolism
	7ACC2 是单羧酸盐转运蛋白抑制剂，IC50为 11 nM。它还是线粒体丙酮酸转运的有效抑制剂，可抑制乳酸涌入，通过抑制乳酸通量来发挥抗癌作用。
T9031	MCU-i4	Others; Mitochondrial Metabolism	Metabolism; Others
	MCU-i4 阻断IP3依赖的线粒体 Ca2+的摄取，是一种新型 MCU 负调节剂，可结合 MICU1 并损害肌肉细胞生长。
T14497	BAM 15	OXPHOS; Mitochondrial Metabolism	Apoptosis; Metabolism
	BAM 15 是一种线粒体质子解偶联剂，也是一种氧化磷酸化解偶联剂。
T19428	Mito-TEMPO	Reactive Oxygen Species; Mitochondrial Metabolism	Immunology/Inflammation; Metabolism; NF-κB
	Mito-TEMPO 是一种线粒体靶向超氧化物歧化酶的模拟物。Mito-TEMPO 可以清除超氧化物和烷基自由基，防止线粒体的氧化、坏死和凋亡。
T15241	ER-000444793	Others; Mitochondrial Metabolism	Metabolism; Others
	ER-000444793 是一种线粒体通透性转换孔开放抑制剂。它能够抑制 mPTP，IC50=2.8 μM。
T10706	CCI-006	Mitochondrial Metabolism	Metabolism
	CCI-006 是一种 MLL 重排白血病细胞的选择性抑制剂和化学增敏剂。它能够抑制线粒体呼吸，造成 MLL-r 白血病细胞亚群中无法克服的线粒体去极化和促凋亡未折叠蛋白反应。
T8732	CTPI-2	Others; Mitochondrial Metabolism	Metabolism; Others
	CTPI-2 是一种特异性线粒体柠檬酸盐载体SLC25A1抑制剂，KD=3.5 μM，具有抗肿瘤作用。它能够抑制糖酵解、PPARγ 及其下游靶点葡萄糖转运蛋白 GLUT4。它阻断非酒精性脂肪性肝炎逆转脂肪变性的显著改变，防止演变为脂肪性肝炎，减少肝脏和脂肪组织中炎性巨噬细胞的浸润，并显著减轻由高脂肪饮食引起的肥胖。
T9169	MPP+ iodide	Mitochondrial Metabolism; Autophagy	Autophagy; Metabolism
	MPP+ iodide 是一种 5-羟色胺转运体的高亲和力底物，也是一种神经毒素 MPTP 的有毒代谢物，通过选择性破坏黑质多巴胺能神经元，在动物模型中引起帕金森病症状。它被多巴胺转运体吸收进入多巴胺能神经元，通过影响呼吸链复合体 I 对线粒体发挥神经毒性作用。
T4639	Azemiglitazone MSDC 0602	Mitochondrial Metabolism; mTOR	Metabolism; PI3K/Akt/mTOR signaling
	Azemiglitazone (MSDC 0602) 是一种 PPARγ 保留的噻唑烷二酮类药物 (TZD)，与能够线粒体丙酮酸载体 (MPC) 相互作用并抑制其活性，降低 pparγ 介导的副作用的风险，有用于 2 型糖尿病研究的潜能。
T6157	Devimistat CPI-613,辛酸,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid	Apoptosis; Dehydrogenase; Mitochondrial Metabolism	Apoptosis; Metabolism
	Devimistat (6,8-Bis(benzylthio)octanoic acid) 是一种线粒体代谢抑制剂，还是一种lipoic acid 拮抗剂，能阻断线粒体能量代谢，诱导多种癌细胞凋亡。
T2498	Adjudin AF-2364	Chloride channel; Mitochondrial Metabolism	Membrane transporter/Ion channel; Metabolism
	Adjudin (AF-2364) 是广泛研究的男性避孕试剂，可通过抑制 NF-κB 通路来减弱小胶质细胞的活化。
T5827	BI-6C9	Apoptosis; Others; Mitochondrial Metabolism	Apoptosis; Metabolism; Others
	BI-6C9 是一种高特异性的 BH3 相互作用结构域抑制剂，可阻止线粒体外膜电位和线粒体分裂，并保护细胞免受线粒体凋亡诱导因子释放和不依赖 caspase 的细胞死亡。
T16342	KL1333 NQO1 activator 1	NADPH; Mitochondrial Metabolism	Metabolism
	KL1333 (NQO1 activator 1) 是口服NAD+调节剂，与 NAD(P)H: 醌氧化还原酶 1 作为底物反应。它改善线粒体脑肌病、乳酸酸中毒和中风样发作成纤维细胞的能量代谢和线粒体功能障碍。它对顺铂诱导的小鼠耳蜗培养耳毒性的保护作用。
T0239	Lonidamine AF1890,氯尼达明,DICA,Diclondazolic Acid	Apoptosis; Hexokinase; Mitochondrial Metabolism	Apoptosis; Metabolism
	Lonidamine (Diclondazolic Acid) 是一种抗肿瘤药物，是己糖激酶、线粒体丙酮酸载体和质膜单羧酸转运蛋白抑制剂，同时也抑制线粒体复合物 II。
T5337	IACS-010759 IACS-10759,IACS 10759,IACS10759	Apoptosis; Others; Mitochondrial Metabolism	Apoptosis; Metabolism; Others
	IACS-010759 是一种口服有效的线粒体氧化磷酸化复合物 I 抑制剂。它在依赖 OXPHOS 的脑癌和急性髓性白血病模型中抑制增殖并诱导细胞凋亡，有研究复发/难治性 AML 和实体瘤潜力。
T6834	FCCP Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone	ATPase; Mitochondrial Metabolism	Membrane transporter/Ion channel; Metabolism
	FCCP (Trifluoromethoxy carbonylcyanide phenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂，线粒体质子载体解偶联剂。FCCP 常被用作细胞凋亡诱导剂。
T8308	NL-1	Mitochondrial Metabolism; Autophagy	Autophagy; Metabolism
	NL-1 是一种mitoNEET 抑制剂，具有抗白血病作用。它抑制 REH 和 REH/Ara-C 细胞生长，IC50分别为 47.35 µM 和 56.26 µM。
T8500	VLX600	OXPHOS; Mitochondrial Metabolism; Autophagy	Apoptosis; Autophagy; Metabolism
	VLX600 是一种铁螯合氧化磷酸化抑制剂，是一种细胞渗透性抗癌剂。它通过减少肿瘤细胞中的线粒体氧化磷酸化起作用。
T8366	Mitochonic acid 5 MA-5	Mitochondrial Metabolism	Metabolism
	Mitochonic acid 5 (MA-5) 能够调节线粒体 ATP 合成，可与线粒体结合，并改善肾小管和心肌细胞损伤。
T4441	UK-5099 UK 5099,PF-1005023,UK5099	Others; Mitochondrial Metabolism	Metabolism; Others
	UK-5099 (PF-1005023) 是一种有效的线粒体丙酮酸转运蛋白(MPC) 抑制剂，抑制丙酮酸依赖性 O2消耗的 IC50值为50 nM。
T2607	MSDC 0160 CAY10415,Mitoglitazone,MSDC0160,MSDC-0160	Others; IGF-1R; Mitochondrial Metabolism	Metabolism; Others; Tyrosine Kinase/Adaptors
	MSDC 0160 (CAY10415) 是一种线粒体丙酮酸载体(MPC) 的调节剂，也是调节噻唑烷二酮的线粒体靶标 (mTOT) 的胰岛素增敏剂。它是一种噻唑烷二酮 (TZD)，具有抗糖尿病和神经保护活性作用。它具有用于阿尔茨海默氏病的潜力。
T9235	GW604714X 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-	Mitochondrial Metabolism	Metabolism
	GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) 是一种高度特异性的线粒体丙酮酸载体抑制剂，Ki<0.1 nM。它是一种线粒体呼吸抑制剂。它也能抑制质膜单羧酸转运体的 L-乳酸转运，但浓度比 MPC 的大 4 个数量级。
T0412	Idebenone 艾地苯醌,CV-2619	Apoptosis; Antioxidant; Mitochondrial Metabolism	Apoptosis; Metabolism; oxidation-reduction
	Idebenone (CV-2619) 是一种线粒体保护剂，具有神经保护功效，可用于研究阿尔茨海默病、亨廷顿舞蹈病，可透过血脑屏障，诱导细胞凋亡。
T7629	Olesoxime NSC 21311,TRO 19622,奥利索西	Mitochondrial Metabolism	Metabolism
	Olesoxime (TRO 19622) 是一种靶向线粒体的神经保护性试剂，能够促进细胞存活，其 EC50=3.2±0.2 µM。
T1640	Ciprofloxacin Ciproxan,环丙沙星,Ciprobay,Bay o 9867,Bay-09867	Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Ciprofloxacin (Bay-09867) 是一种有高抗菌活性的氟喹诺酮类抗生素。
T9211	Mito-LND Mito-Loidamine	OXPHOS; Reactive Oxygen Species; Mitochondrial Metabolism; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Mito-LND (Mito-Loidamine) 是一种有口服活性和靶向线粒体的氧化磷酸化抑制剂。它抑制线粒体生物能，刺激活性氧的形成，并诱导肺癌细胞自噬细胞死亡。
T1634	Glibenclamide 格列本脲,Glyburide	Potassium Channel; Mitochondrial Metabolism; CFTR; P-gp; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Glibenclamide (Glyburide) 是一种具有口服活性的 ATP 敏感的 K+通道抑制剂，可研究糖尿病和肥胖。它抑制 P-糖蛋白，可直接结合并阻断 KATP 的 SUR1亚基并抑制囊性纤维化跨膜传导调节蛋白。它通过诱导膜离子通透性干扰线粒体生物能，可诱导自噬。
T5363	Tempo 2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy	Free radical scavengers; Reactive Oxygen Species; DNA/RNA Synthesis; Mitochondrial Metabolism	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Tempo (2,2,6,6-Tetramethylpiperidinooxy) 可用作自由基清除剂、有机合成中的试剂和电子自旋共振光谱中的结构探针。它可在催化循环中使超氧化物歧化，也可诱导DNA 链断裂。
T7486	Imeglimin hydrochloride EMD 387008 hydrochloride,(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐	Reactive Oxygen Species; Mitochondrial Metabolism	Immunology/Inflammation; Metabolism; NF-κB
	Imeglimin hydrochloride (EMD 387008 hydrochloride) 是一种口服降糖剂。Imeglimin 可改善胰岛素敏感性，能够抑制活性氧的产生、增加线粒体 DNA、改善线粒体功能。
T0250	Ciprofloxacin monohydrochloride Bay-09867 (hydrochloride),Ciprofloxacin HCl,盐酸环丙沙星,环丙沙星盐酸盐,Ciprofloxacin hydrochloride	DNA gyrase; Topoisomerase; Antibacterial; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) 是一种高抗菌活性的氟喹诺酮类抗生素。
T22381	Antimalarial agent 14 4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone	Others	Others
	Antimalarial agent 14 (NSC-102533) 是一种生物活性化学品。
T7487	Speract 精子活化肽	Others; Mitochondrial Metabolism	Metabolism; Others
	Speract 是调节精子活力的海胆蛋肽，也能够刺激精子线粒体代谢。
T8841	IMT1 Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)	Others; DNA/RNA Synthesis; Mitochondrial Metabolism	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) 是一种非竞争特异性人类线粒体 RNA 聚合酶(POLRMT) 抑制剂，可引起 POLRMT 的构象变化，以剂量依赖性方式阻断底物结合和转录。它可降低脱氧核苷三磷酸水平和柠檬酸循环中间体，导致细胞氨基酸水平显著消耗，有用于线粒体转录等相关疾病的研究潜力。
T13748	L-2-Hydroxyglutaric acid disodium S-2-羟基戊二酸,(S)-2-Hydroxyglutaric acid disodium	Histone Demethylase; Mitochondrial Metabolism	Chromatin/Epigenetic; Metabolism
	L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) 是一种表观遗传修饰因子，是肾癌中的表观遗传修饰剂和推定的癌代谢物，可用于肾癌的相关研究。它抑制线粒体肌酸激酶活性，Km 和 Ki 分别为 2.52 mM 和11.13 mM。它可抑制组蛋白去甲基化酶，从而促进组蛋白甲基化。
T7081	CCCP Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone,羰基氰化氯苯腙	Apoptosis; IκB/IKK; COX; Mitochondrial Metabolism; STING; IFNAR; Antibacterial	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) 是一种氧化磷酸化 (OXPHOS) 抑制剂，线粒体质子载体解偶联剂。CCCP 抑制 STING 及其下游信号分子 TBK1 和 IRF3 的激活。
T7487L	Speract TFA(76901-59-2(free base))	Others	Others
	Speract TFA(76901-59-2(free base)) 是一种海胆卵肽，可调节精子活力，也可刺激精子线粒体代谢。
T9768L	Ninerafaxstat trihydrochloride Ninerafaxstat trihydrochloride(2254741-41-6 Free base)	Others	Others
	Ninerafaxstat trihydrochloride 将细胞代谢由脂肪酸氧化转变为葡萄糖氧化。 Ninerafaxstat trihydrochloride 改善整体线粒体呼吸并减少脂肪酸氧化，从而抑制癌细胞的增殖和生长。
T38715	MSDC-0602K MSDC-0602K,Azemiglitazone potassium	PPAR	DNA Damage/DNA Repair; Metabolism
	MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both ...
T10035	10,12-Tricosadiynoic acid TDA,TCDA	Acyltransferase	Metabolism
	10,12-Tricosadiynoic acid 是一种口服有效的酰基辅酶 A 氧化酶-1 (ACOX1) 抑制剂，具有高特异性，选择性，高亲和力的特点。10,12-Tricosadiynoic acid 可改善线粒体脂质和 ROS 代谢，在高脂饮食或肥胖引起的代谢性疾病中有研究的价值。
T27417L	Glutathione arsenoxide hydrochloride GSAO HCl,Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)	Apoptosis; AChR	Apoptosis; Neuroscience
	Glutathione arsenoxide hydrochloride (Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)) 是一种潜在的抗癌活性分子和肿瘤代谢抑制剂。Glutathione arsenoxide hydrochloride 靶向线粒体内膜腺嘌呤核苷酸转移酶 (ANT)，对细胞增殖有抑制作用，促进细胞凋亡。Glutathione arsenoxide hydrochloride 可用于识别如蛋白质二硫异构酶一样的细胞表面蛋白质。
T33511	ms2i6A ms2i6-2-6,ms2i6 2 6
	ms2i6A is a mitochondrial tRNA-specific modification, which regulates efficient mitochondrial translation and energy metabolism in mammals.
T70032	NCI-006
	NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.
T9768	Ninerafaxstat	Others	Others
	Ninerafaxstat 可以将细胞代谢从脂肪酸氧化转变为葡萄糖氧化，降低脂肪酸氧化，改善线粒体呼吸。
T79226	AMPK activator 11	Mitochondrial Metabolism	Metabolism
	AMPK activator11 是一种抗肿瘤活性纳米级化合物，有效针对多种CRC。通过激活AMPK及上调OXPHOS（mitochondrial metabolism），该化合物能选择性抑制RKO异种移植物生长，应用于肿瘤和代谢性疾病研究领域。
T78580	Erythronic acid	Endogenous Metabolite	Metabolism
	Erythronic acid为一糖类内源性代谢物，关键于高尿酸血症发病及其改善过程，且与转醛缩酶缺乏症相关联的线粒体功能障碍相关，常用于代谢性疾病研究。

化合物

Cat.No: T9372

Target: Mitochondrial Metabolism

Cat.No: T9777

Target: Mitochondrial Metabolism

Cat.No: T15373

Target: ATPase, Mitochondrial Metabolism

Perhexiline maleate

Cat.No: T12408

Target: Others, Mitochondrial Metabolism

Mitochondrial fusion promoter M1

Cat.No: T9232

Target: Mitochondrial Metabolism

Cat.No: T1768

Target: Mitochondrial Metabolism, Monocarboxylate transporter

Cat.No: T9031

Target: Others, Mitochondrial Metabolism

Cat.No: T14497

Target: OXPHOS, Mitochondrial Metabolism

Cat.No: T19428

Target: Reactive Oxygen Species, Mitochondrial Metabolism

Cat.No: T15241

Target: Others, Mitochondrial Metabolism

Cat.No: T10706

Target: Mitochondrial Metabolism

Cat.No: T8732

Target: Others, Mitochondrial Metabolism

Cat.No: T9169

Target: Mitochondrial Metabolism, Autophagy

Cat.No: T4639

Synonym: MSDC 0602

Target: Mitochondrial Metabolism, mTOR

Cat.No: T6157

Synonym: CPI-613,辛酸,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid

Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism

Cat.No: T2498

Synonym: AF-2364

Target: Chloride channel, Mitochondrial Metabolism

Cat.No: T5827

Target: Apoptosis, Others, Mitochondrial Metabolism

Cat.No: T16342

Synonym: NQO1 activator 1

Target: NADPH, Mitochondrial Metabolism

Cat.No: T0239

Synonym: AF1890,氯尼达明,DICA,Diclondazolic Acid

Target: Apoptosis, Hexokinase, Mitochondrial Metabolism

Cat.No: T5337

Synonym: IACS-10759,IACS 10759,IACS10759

Target: Apoptosis, Others, Mitochondrial Metabolism

Cat.No: T6834

Synonym: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone,Trifluoromethoxy carbonylcyanide phenylhydrazone

Target: ATPase, Mitochondrial Metabolism

Cat.No: T8308

Target: Mitochondrial Metabolism, Autophagy

Cat.No: T8500

Target: OXPHOS, Mitochondrial Metabolism, Autophagy

Mitochonic acid 5

Cat.No: T8366

Synonym: MA-5

Target: Mitochondrial Metabolism

Cat.No: T4441

Synonym: UK 5099,PF-1005023,UK5099

Target: Others, Mitochondrial Metabolism

Cat.No: T2607

Synonym: CAY10415,Mitoglitazone,MSDC0160,MSDC-0160

Target: Others, IGF-1R, Mitochondrial Metabolism

Cat.No: T9235

Synonym: 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-

Target: Mitochondrial Metabolism

Cat.No: T0412

Synonym: 艾地苯醌,CV-2619

Target: Apoptosis, Antioxidant, Mitochondrial Metabolism

Cat.No: T7629

Synonym: NSC 21311,TRO 19622,奥利索西

Target: Mitochondrial Metabolism

Cat.No: T1640

Synonym: Ciproxan,环丙沙星,Ciprobay,Bay o 9867,Bay-09867

Target: Topoisomerase, Antibacterial, Antibiotic

Cat.No: T9211

Synonym: Mito-Loidamine

Target: OXPHOS, Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

Cat.No: T1634

Synonym: 格列本脲,Glyburide

Target: Potassium Channel, Mitochondrial Metabolism, CFTR, P-gp, Autophagy

Cat.No: T5363

Synonym: 2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy

Target: Free radical scavengers, Reactive Oxygen Species, DNA/RNA Synthesis, Mitochondrial Metabolism

Imeglimin hydrochloride

Cat.No: T7486

Synonym: EMD 387008 hydrochloride,(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐

Target: Reactive Oxygen Species, Mitochondrial Metabolism

Ciprofloxacin monohydrochloride

Cat.No: T0250

Synonym: Bay-09867 (hydrochloride),Ciprofloxacin HCl,盐酸环丙沙星,环丙沙星盐酸盐,Ciprofloxacin hydrochloride

Target: DNA gyrase, Topoisomerase, Antibacterial, Antibiotic

Antimalarial agent 14

Cat.No: T22381

Synonym: 4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone

Target: Others

Cat.No: T7487

Synonym: 精子活化肽

Target: Others, Mitochondrial Metabolism

Cat.No: T8841

Synonym: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)

Target: Others, DNA/RNA Synthesis, Mitochondrial Metabolism

L-2-Hydroxyglutaric acid disodium

Cat.No: T13748

Synonym: S-2-羟基戊二酸,(S)-2-Hydroxyglutaric acid disodium

Target: Histone Demethylase, Mitochondrial Metabolism

Cat.No: T7081

Synonym: Carbonyl Cyanide m-Chlorophenylhydrazone,Carbonyl cyanide 3-chlorophenylhydrazone,羰基氰化氯苯腙

Target: Apoptosis, IκB/IKK, COX, Mitochondrial Metabolism, STING, IFNAR, Antibacterial

Speract TFA(76901-59-2(free base))

Cat.No: T7487L

Target: Others

Ninerafaxstat trihydrochloride

Cat.No: T9768L

Synonym: Ninerafaxstat trihydrochloride(2254741-41-6 Free base)

Target: Others

Cat.No: T38715

Synonym: MSDC-0602K,Azemiglitazone potassium

Target: PPAR

10,12-Tricosadiynoic acid

Cat.No: T10035

Synonym: TDA,TCDA

Target: Acyltransferase

Glutathione arsenoxide hydrochloride

Cat.No: T27417L

Synonym: GSAO HCl,Glutathione arsenoxide hydrochloride(1271726-51-2 Free base)

Target: Apoptosis, AChR

Cat.No: T33511

Synonym: ms2i6-2-6,ms2i6 2 6

Cat.No: T70032

Cat.No: T9768

Target: Others

AMPK activator 11

Cat.No: T79226

Target: Mitochondrial Metabolism

Erythronic acid

Cat.No: T78580

Target: Endogenous Metabolite

Cat. No.	Product Name	Target	Signaling Pathways
T8433	HQNO	Mitochondrial Metabolism	Metabolism
	HQNO 是一种电子传递链抑制剂，对 complex III 的Kd 值为 64 nM，由P. aeruginosa 产生的。它是许多物种的线粒体NDH-2的有效抑制剂。
TN1586	Dihydrorotenone	Apoptosis; Mitochondrial Metabolism	Apoptosis; Metabolism
	Dihydrorotenone 是一种线粒体抑制剂，是天然杀虫剂。它通过触发内质网应激并激活 p38 信号通路来诱导人浆细胞凋亡，可能诱发帕金森综合症。
T14140	Agaric acid 落叶松蕈酸,Agaricinic Acid	Mitochondrial Metabolism; AChR	Metabolism; Neuroscience
	Agaric acid (Agaricinic Acid) 来一种自真菌部落的Polyporus officinalis 和Polyporus igniarius。它可促进积累的 Ca2+流出，跨膜电位的破坏和线粒体肿胀。它通过其与腺嘌呤核苷酸转位酶的相互作用诱导线粒体通透性转变。它用于调节脂类代谢。
T7922	Kresoxim-Methyl	Others; Mitochondrial Metabolism; Antifungal	Metabolism; Microbiology/Virology; Others
	Kresoxim-methyl 是一种嗜球果伞素类杀菌剂，可抑制复合体 III 的呼吸，抑制苹果园分离株 V. inaequalis 的分生孢子萌发。
T0938	Thiabendazole 2-(4-Thiazolyl)benzimidazole,噻菌灵	Microtubule Associated; Mitochondrial Metabolism; Parasite	Cytoskeletal Signaling; Metabolism; Microbiology/Virology
	Thiabendazole (2-(4-Thiazolyl)benzimidazole) 是具有驱虫特性的苯并咪唑衍生物。
T5645	Nerol Cis-Geraniol,橙花醇,Neryl alcohol	Apoptosis; Reactive Oxygen Species; Mitochondrial Metabolism; Endogenous Metabolite; Antifungal	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Nerol (Neryl alcohol) 是橙花油的一种单萜, 它通过增强 Ca2+和ROS 来触发线粒体功能障碍并诱导凋亡，具有抗真菌活性。它可减轻哺乳动物心脏中哇巴因引发的心律失常的严重程度。
T2970	Rotenone Rotenon,鱼藤酮,Paraderil,Barbasco,Rotocide,Dactinol	Apoptosis; Dehydrogenase; Mitochondrial Metabolism; p53; Autophagy	Apoptosis; Autophagy; Metabolism
	Rotenone (Rotocide) 属于天然产物，是一种植物杀虫剂。Rotenone 是一种线粒体电子传递复合物 I 抑制剂，可以促进线粒体产生活性氧，并诱导细胞凋亡。
TN1362	Afzelin 阿福豆苷,Kaempferol-3-O-rhamnoside	PTEN; p38 MAPK; TNF; Mitochondrial Metabolism; Antibacterial; Prostaglandin Receptor; Autophagy	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Afzelin (Kaempferol-3-O-rhamnoside) 具有多种细胞活性，例如 DNA 保护、抗菌、抗氧化和抗炎以及 UV 吸收活性，并且可以通过 UV 吸收和细胞活性的组合保护人体皮肤免受 UVB 引起的损伤。 Afzelin 减轻线粒体损伤，增强线粒体生物合成并降低线粒体自噬相关蛋白、parkin 和 putative kinase 1 的水平。
T3898	Schaftoside 夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside	Dynamin; Antioxidant; TLR; MyD88; Mitochondrial Metabolism; Autophagy	Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; oxidation-reduction
	Schaftoside (APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE) 是在多种中草药中发现的一种黄酮类天然产物。它抑制 TLR4 和 Myd88 表达，还降低 Drp1 表达和磷酸化，并减少线粒体分裂，具有抗氧化和抗癌活性。
T2A2532	L-Histidine Glyoxaline-5-alanine,L-(-)-Histidine,L-组氨酸,histidine,组氨酸,L-Hisidine	Mitochondrial Metabolism; Endogenous Metabolite	Metabolism
	L-Histidine (L-(-)-Histidine) 是人类生长和组织修复所需的一种半必需氨基酸(儿童应从食物中获得)。 L-Histidine 是线粒体谷氨酰胺转运的抑制剂。
T2901	Daidzin NPI-031D,大豆苷,Daidzein 7-O-glucoside,Daidzoside,黄豆苷,Daidzein 7-glucoside	Dehydrogenase; Reverse Transcriptase; Mitochondrial Metabolism	Metabolism; Microbiology/Virology
	Daidzin (Daidzoside) 是从大豆中分离出来的一种异黄酮，具有抗氧化、抗癌和抗动脉粥样硬化的活性。
T0200	α-Lipoic Acid Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid,α-硫辛酸,硫辛酸	Apoptosis; NF-κB; HIV Protease; Mitochondrial Metabolism; Endogenous Metabolite	Apoptosis; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	α-Lipoic Acid (DL-α-Lipoic acid) 是线粒体酶复合物的重要辅助因子，是一种抗氧化剂，可抑制NF-κB 依赖性的HIV-1LTR 活化。它还可诱导内质网应激介导的肝癌细胞凋亡。
T5564	Tricarballylic acid β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,三碳烯丙酸,Carballylic acid,Propane-1,2,3-tricarboxylic acid,丙三酸	aconitase; Mitochondrial Metabolism	Metabolism
	Tricarballylic acid (Carballylic acid) 是三碳烯丙酸酯的共轭酸，是一种乌头酸水合酶的竞争性抑制剂，其 Ki= 0.52 mM。
T22235	Lipoic acid R-(+)-硫辛酸,硫辛酸,R-(+)-Thioctic acid,(R)-(+)-1,2-Dithiolane-3-pentanoic acid,(R)-(+)-α-Lipoic acid	Reactive Oxygen Species; Mitochondrial Metabolism; Endogenous Metabolite	Immunology/Inflammation; Metabolism; NF-κB
	Lipoic acid (R-(+)-Thioctic acid) ((R)-(+)-α-Lipoic acid) 是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。与外消旋 Lipoic acid 相比，Lipoic acid ((R)-(+)-α-Lipoic acid)更有效。
TN4883	Quinine sulfate dihydrate 奎宁树	Others	Others
	Quinine sulfate dihydrate 在钾通道阻滞剂中起主要作用。它也被用作抗疟疾、抗胆碱能、抗高血压和降糖药。它抑制线粒体atp 调节的钾通道。它也被用来研究生物结晶血红素，血红素，在疟疾寄生虫的代谢和研究血红素(FP)复合物的毒性。
T5245	N-Isovaleroylglycine N-异戊酰氨基乙酸,Isovaleroylglycine,N-Isovalerylglycine	Others; Endogenous Metabolite	Metabolism; Others
	N-Isovaleroylglycine (Isovaleroylglycine) 是酰基甘氨酸，能够作为体重提高和肥胖的生物标记物。
T4880	L-Dihydroorotic acid	Others; Endogenous Metabolite	Metabolism; Others
	L-Dihydroorotic acid 是一种能够通过二氢乳清酶，能够逆水解产生的无环 L-脲基琥珀酸。
T5300	Ammonium formate 甲酸铵,Formic acid ammonium salt	Others	Others
	Ammonium formate (Formic acid ammonium salt) 是最简单的羧酸。它通过抑制细胞色素氧化酶活性（电子传递链的末端电子受体）来负责代谢性酸中毒和破坏线粒体电子传递和能量产生。
T5S1632	Barlerin 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01	VEGFR; TNF; NF-κB; Akt; Caspase	Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷，从中国西藏民间药用植物中分离得到，能够抑制NF-κB 活性。
T4S2326	Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside	ERK; p38 MAPK; NF-κB; JNK	MAPK; NF-κB
	Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷，可用于炎症疾病的研究和促进血液循环。它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应，用于炎性过敏性疾病中的潜能。
T37177	Norcholic Acid
	Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4

天然产物

Cat.No: T8433

Target: Mitochondrial Metabolism

Dihydrorotenone

Cat.No: TN1586

Target: Apoptosis, Mitochondrial Metabolism

Cat.No: T14140

Synonym: 落叶松蕈酸,Agaricinic Acid

Target: Mitochondrial Metabolism, AChR

Kresoxim-Methyl

Cat.No: T7922

Target: Others, Mitochondrial Metabolism, Antifungal

Cat.No: T0938

Synonym: 2-(4-Thiazolyl)benzimidazole,噻菌灵

Target: Microtubule Associated, Mitochondrial Metabolism, Parasite

Cat.No: T5645

Synonym: Cis-Geraniol,橙花醇,Neryl alcohol

Target: Apoptosis, Reactive Oxygen Species, Mitochondrial Metabolism, Endogenous Metabolite, Antifungal

Cat.No: T2970

Synonym: Rotenon,鱼藤酮,Paraderil,Barbasco,Rotocide,Dactinol

Target: Apoptosis, Dehydrogenase, Mitochondrial Metabolism, p53, Autophagy

Cat.No: TN1362

Synonym: 阿福豆苷,Kaempferol-3-O-rhamnoside

Target: PTEN, p38 MAPK, TNF, Mitochondrial Metabolism, Antibacterial, Prostaglandin Receptor, Autophagy

Cat.No: T3898

Synonym: 夏佛塔苷,APIGENIN-6-GLUCOSIDE-8-ARABINOSIDE,Shaftoside

Target: Dynamin, Antioxidant, TLR, MyD88, Mitochondrial Metabolism, Autophagy

Cat.No: T2A2532

Synonym: Glyoxaline-5-alanine,L-(-)-Histidine,L-组氨酸,histidine,组氨酸,L-Hisidine

Target: Mitochondrial Metabolism, Endogenous Metabolite

Cat.No: T2901

Synonym: NPI-031D,大豆苷,Daidzein 7-O-glucoside,Daidzoside,黄豆苷,Daidzein 7-glucoside

Target: Dehydrogenase, Reverse Transcriptase, Mitochondrial Metabolism

Cat.No: T0200

Synonym: Thioctic acid,DL-α-Lipoic acid,(±)-α-Lipoic acid,α-硫辛酸,硫辛酸

Target: Apoptosis, NF-κB, HIV Protease, Mitochondrial Metabolism, Endogenous Metabolite

Tricarballylic acid

Cat.No: T5564

Synonym: β-Carboxyglutaric acid,1,2,3-Propanetricarboxylic acid,三碳烯丙酸,Carballylic acid,Propane-1,2,3-tricarboxylic acid,丙三酸

Target: aconitase, Mitochondrial Metabolism

Cat.No: T22235

Synonym: R-(+)-硫辛酸,硫辛酸,R-(+)-Thioctic acid,(R)-(+)-1,2-Dithiolane-3-pentanoic acid,(R)-(+)-α-Lipoic acid

Target: Reactive Oxygen Species, Mitochondrial Metabolism, Endogenous Metabolite

Quinine sulfate dihydrate

Cat.No: TN4883

Synonym: 奎宁树

Target: Others

N-Isovaleroylglycine

Cat.No: T5245

Synonym: N-异戊酰氨基乙酸,Isovaleroylglycine,N-Isovalerylglycine

Target: Others, Endogenous Metabolite

L-Dihydroorotic acid

Cat.No: T4880

Target: Others, Endogenous Metabolite

Ammonium formate

Cat.No: T5300

Synonym: 甲酸铵,Formic acid ammonium salt

Target: Others

Cat.No: T5S1632

Synonym: 8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01

Target: VEGFR, TNF, NF-κB, Akt, Caspase

Cat.No: T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Cat.No: T37177

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